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The earliest historical attempts at blood transfusions often had lethal results. These results led to the investigation and discovery of blood types, as well as a deeper understanding of the importance of antigen/antibody interactions. In this investigation, students will utilize Innovating Science’s new simulated blood to determine the ABO/Rh blood type of four individuals, one in need of a transfusion. Based on the results, students will then determine which of three potential donors would provide the best match for the patient in need. Kit contains enough materials for 10 groups. Teacher’s Manual and Student Study Guide copymasters are included.